A winter weather advisory has been issued for most of Maryland, which will see its second snowstorm of the week starting Thursday night. The next round of snowfall could make Friday’s morning commute a challenge.

The advisory takes effect at 9 p.m. Thursday and runs until 5 a.m. Friday, the National Weather Service said.

Areas included in the advisory are: Cecil, Baltimore, Prince George’s, Anne Arundel, Charles, St. Marys, Calvert, Montgomery, Howard and Harford counties.

The National Weather Service is predicting 2 to 4 inches of snow in the Washington and Baltimore metropolitan areas, parts of central and southern Maryland, and portions of northern Virginia.

Isolated high snowfall amounts of up to 6 inches are possible, the forecast said.